5 MEMBERED RING ANALOGS OF NIFEDIPINE .2. PHOTOCHEMISTRY OF DIMETHYL ,6-DIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATES WITH 4-(2-NITRO-3-FURYL) AND 4-(2-NITRO-3-THIENYL) SUBSTITUENTS

Authors
GORLITZER K DOBBERKAU PM JONES PG
Citation
K. Gorlitzer et al., 5 MEMBERED RING ANALOGS OF NIFEDIPINE .2. PHOTOCHEMISTRY OF DIMETHYL ,6-DIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATES WITH 4-(2-NITRO-3-FURYL) AND 4-(2-NITRO-3-THIENYL) SUBSTITUENTS, Die Pharmazie, 51(6), 1996, pp. 392-396
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
51
Issue
6
Year of publication
1996
Pages
392 - 396
Database
ISI
SICI code
0031-7144(1996)51:6<392:5MRAON>2.0.ZU;2-O
Abstract
Irradiation of the 1,4-dihydropyridines (DHP) 1 and 5 with UV-A light yields the nitroso compounds 3 and 6, which add solvents that contain hydroxyl groups to form the oximes 4, 7 and 8. Compound 7a reacts with hydrochloric acid to give a mixture consisting of the (Z)-2-hydroxy-i mino-5-thiophenone 15 and the chloro-substituted thieno[2,3-b] [2,7]na phthyridine 16. The structure of 15 was elucidated by X-ray diffractio n.