OCCURRENCE OF PAROXYSMAL SYNCHRONOUS EEG DISCHARGES IN SUBCORTICAL ARTERIOSCLEROTIC ENCEPHALOPATHY (BINSWANGER DISEASE)

A 72-year-old patient with von Recklinghausen's disease showed akineti c mutism within 6 months of the onset of dementia. The findings of dif fuse cerebral atrophy on CT and periodic synchronous discharges (PSDs) in EEG suggested Creutzfeldt-Jakob disease. However, autopsy findings of diffuse softening of the subcortical white matter and marked arter iosclerotic changes of the subcortical arterioles with sparing of the cortex in the cerebrum confirmed a diagnosis of Binswanger's disease. Binswanger's disease should be included in the differential diagnosis of dementia showing PSDs in EEG.