OBSERVATION OF RESOLVED GLUCOSE SIGNALS IN H-1-NMR SPECTRA OF THE HUMAN BRAIN AT 4 TESLA

Measurement of the resonances of glucose between 3.2 and 3.9 ppm in H- 1 NMR spectra from the human brain is difficult due to spectral overla p with peaks from more concentrated metabolites, The H1 resonance of a lpha-D-glucose at 5.23 ppm is resolved from other metabolite peaks, bu t potentially overlaps with the intense water signal at 4.72 ppm. This paper demonstrates that the increased resolution at 4 Tesla permits t o suppress the water signal sufficiently to reliably detect glucose di rectly at 5.23 ppm by H-1 MRS and the estimated peak intensity is cons istent with previous C-13 NMR quantification.