MALDI FOR FAST DNA ANALYSIS AND SEQUENCING

Authors
CHEN CH TARANENKO NI ZHU YF ALLMAN SL
Citation
Ch. Chen et al., MALDI FOR FAST DNA ANALYSIS AND SEQUENCING, Laboratory robotics and automation, 8(2), 1996, pp. 87-99
Citations number
68
Categorie Soggetti
Computer Application, Chemistry & Engineering","Chemistry Analytical","Robotics & Automatic Control
Journal title
Laboratory robotics and automation → ACNP
ISSN journal
08957533
Volume
8
Issue
2
Year of publication
1996
Pages
87 - 99
Database
ISI
SICI code
0895-7533(1996)8:2<87:MFFDAA>2.0.ZU;2-V
Abstract
Matrix-assisted laser desorption/ionization (MALDI) has been pursued f or fast DNA analysis and sequencing. In this article, recent progress on detecting large oligonucleotides is reviewed. The potential applica tion of MALDI for population screening for disease diagnosis is discus sed. The approach of using MALDI for DNA sequencing is presented. Disc ussion on the use of robotic and automation to speed up the mass spect rometer sequencing process is also included. (C) 1996 John Wiley & Son s, Inc.