This article describes a method for doing therapy that uses multisyste
mic themes that combine meaning and action to facilitate therapeutic c
hange. By identifying central themes that operate at the individual, d
yadic, triadic, whole family, inter-generational, and sociocultural le
vels, the therapist is able to develop effective interview questions a
nd design useful interventions. In this method behavioral symptoms are
framed as a current manifestation of an overarching theme. This orien
tation enables family and therapist to depathologize symptoms and work
collaboratively toward change. Case examples from a wide variety of f
amilies with differing presenting problems, interactional patterns, th
ree-generational histories, and cultural backgrounds, illustrate the e
fficacy of the method.