SPECTROFLUOROMETRIC FLOW-INJECTION METHOD FOR THE SUCCESSIVE DETERMINATION OF CHLOROXINE AND CHLORQUINALDOL IN PHARMACEUTICAL PREPARATIONS

A flow-injection method is proposed for the sequential determination o f chloroxine (COX) and chlorquinaldol (CQD) at sub-mu g ml(-1) levels in mixtures. The method is based on the different behaviour of these a nalytes with metal ions. Aluminum(III) only reacts with COX to form a fluorescent complex, whereas cadmium(II) reacts with both analytes for ming fluorescent complexes. The use of two sub-systems, through which aluminum or cadmium are pumped, makes it possible to obtain analytical signals due to the contributions of COX or COX plus CQD, respectively . The features of the method (linearity in the range 0.1-13 mu g ml(-1 ) RSD smaller than 2.5% in all instances and sampling frequency 30 h(- 1)) and the results obtained on application to pharmaceutical preparat ions show its usefulness.