INDONESIAN MEDICINAL-PLANTS .14. CHARACTERIZATION OF 3'-O-CAFFEOYLSWEROSIDE, A NEW SECOIRIDOID GLUCOSIDE, AND KELAMPAYOSIDE-A AND KELAMPAYOSIDE-B, 2 NEW PHENOLIC APIOGLUCOSIDES, FROM THE BARK OF ANTHOCEPHALUS-CHINENSIS (RUBIACEAE)

A new secoiridoid glucoside named 3'-O-caffeoylsweroside (1), and tno new phenolic apioglucosides, named kelampayoside A (4) and kelampayosi de B (6), together with eleven known compounds (five iridoids and six alkaloids), were isolated from the bark of Anthocephalus chinensis (Ru biaceae), an Indonesian medicinal plant from Sumatra Island, Indonesia , The chemical structures of 1, 4 and 6 have been elucidated respectiv ely as 3'-O-caffeoylsweroside (1), antiarol beta-D-apiofuranosyl(1-->6 )-beta-D-glucopyranoside (4), and antiarol 1-O-beta-D-5 caffeolapiofur anosyl(1-->6)-beta-D-glucopyranoside (6) on the bases of their chemica l and physicochemical properties, Among fourteen constituents characte rized, cadambine (13), one of the major indole alkaloidal constituents of A. chinensis, was shown to exhibit moderate growth-inhibitory acti vity against the malarial parasite Plasmodium falciparum (a chloroquin e-resistant K1 strain) cultured in human erythrocytes.