M. Nakakura et al., ELECTROCHEMICAL STABILITY OF DESMOPRESSIN ACETATE DURING IONTOPHORESIS, Chemical and Pharmaceutical Bulletin, 44(6), 1996, pp. 1238-1241
The electrochemical stability of desmopressin acetate (DDAVP) as inves
tigated, lifter a direct current of 1 mA as passed through tno electro
des chosen from platinum, silver and silver chloride, the decompositio
n of DDAVP was observed. The degradation products of DDAVP yielded wit
h a Pt(anode) and AgCl(cathode) pair were similar to those observed in
an anodic donor after in vivo iontophoresis. Although the Ag(anode)/P
t(cathode) degradation pattern of DDAVP or as similar to that of an in
vivo cathodic donor HPLC chromatogram, it was different from that of
the anodic donor. In the anodic system, the stability of DDAVP was ind
ependent of the pH,and decreased with increasing concentration of NaCl
.