EXPERIMENTAL-DETERMINATION AND MATHEMATICAL-MODELING OF PROPYLENE-GLYCOL TRANSPORT FROM SEMISOLID VEHICLES

The penetration of the cosolvent and penetration enhancer propylene gl ycol (PG) into a multilayer membrane system was examined. Consisting o f dodecanol (DD) this acceptor system was used to simulate the interce llular Lipid pathway across the stratum corneum, Vehicles with 10%, 40 % and 60% PG were investigated, Using a pharmacokinetic description ba sed on Fick's first law of diffusion, the transport rate of PG was sim ulated, A parameter estimation was carried out to obtain a kinetic vel ocity parameter k(PG) for the transport, k(PG) depends on the diffusio n coefficient, the area of application, and the pathlength, The data w ere validated by determining confidence intervals, The extent of the p enetration of PG into the lipophilic acceptor system was shown to be q uantitative, The data presented are useful for further investigations to assess the solvent drag effect caused by PG penetration, The multil ayer membrane model was found to provide reasonable results with respe ct to accuracy and reproducibility.