A NOVEL SYNTHESIS OF (+)-AZIMIC ACID

Authors
KIGUCHI T SHIRAKAWA M NINOMIYA I NAITO T
Citation
T. Kiguchi et al., A NOVEL SYNTHESIS OF (+)-AZIMIC ACID, Chemical and Pharmaceutical Bulletin, 44(6), 1996, pp. 1282-1284
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
44
Issue
6
Year of publication
1996
Pages
1282 - 1284
Database
ISI
SICI code
0009-2363(1996)44:6<1282:ANSO(A>2.0.ZU;2-6
Abstract
A combination of 1,3-dipolar cycloaddition of Z-nitrone (2) to the chi ral dipolarophile (3) and subsequent ring transformation of the result ing adducts (4 and 6) to piperidinol (17) has provided a new practical synthesis of 2,3,6-trisubstituted piperidine alkaloid, (+)-azimic aci d (1).