AMINO-ACIDS AND PEPTIDES .28. PREPARATION OF POLY(ETHYLENE GLYCOL) HYBRIDS OF GLN-VAL-VAL-ALA-GLY ANALOGS AND THEIR INHIBITORY EFFECT ON PAPAIN

Authors
KAWASAKI K INOUE S OKADA Y IGUCHI S OKAMOTO H
Citation
K. Kawasaki et al., AMINO-ACIDS AND PEPTIDES .28. PREPARATION OF POLY(ETHYLENE GLYCOL) HYBRIDS OF GLN-VAL-VAL-ALA-GLY ANALOGS AND THEIR INHIBITORY EFFECT ON PAPAIN, Biological & pharmaceutical bulletin, 19(6), 1996, pp. 890-892
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
19
Issue
6
Year of publication
1996
Pages
890 - 892
Database
ISI
SICI code
0918-6158(1996)19:6<890:AAP.PO>2.0.ZU;2-0
Abstract
Gln-Val-Val-Ala-Gly is a sequence which is common in cysteine protease inhibitors. Poly(ethylene glycol) hybrids of Gln-Val-Val-Ala-Gly anal ogs were prepared by the solid phase method by fluorenylmethyloxycarbo nyl chemistry. The hybrid formation of Gln-Val-Val-Ala-Gly resulted in improvement of the solubility and also in enhancement of the inhibito ry effect of the peptide on papain. In addition, the hybrid formation of Gln-Val-Val-Ala-Gly analogs resulted in the enhancement of the inhi bitory effect of the peptide analogs.