STABILITY OF SURAMIN IN AQUEOUS-SOLUTION - POSSIBLE IMPLICATIONS FOR THE SEARCH FOR SURAMIN METABOLITES IN PATIENTS

The stability of an aqueous solution of suramin has been determined. T he only degradation product detectable by HPLC was the amine precursor 2. The decomposition kinetics of suramin at different temperatures ar e shown. Because of first order kinetics the Arrhenius equation could be used to evaluate the decomposition data. A good correlation was obt ained between the reaction constants and the temperature (r = 0.9898). After 42 days at 37 degrees, 2% of suramin are hydrolysed. Possible i mplications of our results for the search for suramin metabolites in p atients are discussed.