CHITOSAN-INDOMETHACIN CONJUGATES - EFFECT OF DIFFERENT SUBSTITUENTS ON THE POLYSACCHARIDE MOLECULE ON DRUG-RELEASE

Authors
ORIENTI I AIEDEH K GIANASI E PONTI C ZECCHI V
Citation
I. Orienti et al., CHITOSAN-INDOMETHACIN CONJUGATES - EFFECT OF DIFFERENT SUBSTITUENTS ON THE POLYSACCHARIDE MOLECULE ON DRUG-RELEASE, Archiv der pharmazie, 329(5), 1996, pp. 245-250
Citations number
19
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
329
Issue
5
Year of publication
1996
Pages
245 - 250
Database
ISI
SICI code
0365-6233(1996)329:5<245:CC-EOD>2.0.ZU;2-0
Abstract
The conjugation of indomethacin with chitosan partially substituted wi th the hydrophilic residues triethylene glycol glutarate and triethyle ne glycol choline ether glutarate is described. Mucoadhesive conjugate s were obtained showing gelling properties both in acid and basic envi ronment. Among the substituents, triethylene glycol choline ether glut arate better enhances the gelling properties of the macromolecules. In all cases the kinetics of drug release from the macromolecules approa ched zero order.