Primary carcinomas of the lacrimal drainage system are rare. These mal
ignant neoplasms typically present as noncompressible, nontender masse
s with low-grade dacyrocystitis and/or unilateral epiphora. Lymph node
metastasis may occur late in the disease course. Complete surgical re
section is the best treatment choice; extensive procedures such as orb
ital exenteration and maxillectomy may be necessary for complete tumor
extirpation. Further adjunctive radiotherapy may improve local contro
l. We present two cases of carcinoma of the lacrimal drainage system,
including one locally controlled tumor with apparent lymph node metast
asis that occurred 21 years after primary treatment. A review of the h
istopathology and literature concerning carcinomas of the lacrimal dra
inage system is presented.