An 18-year-old black woman was initially seen with a 1-year history of
a slowly enlarging midline neck mass. On physical examination this wa
s consistent with a thyroglossal duct cyst. Histologic examination fol
lowing a Sistrunk procedure revealed a Hurthle cell adenoma arising in
a thyroglossal duct cyst. This is the second reported case of a Hurth
le cell adenoma arising in a thyroglossal duct cyst. Neoplasms of thyr
oglossal duct cysts are reviewed.