SYNTHETIC APPROACHES TO 2-PYRROLIDINONE-5-CARBOXALDEHYDE

Authors
DESKUS J SMITH MB SIMANDAN T
Citation
J. Deskus et al., SYNTHETIC APPROACHES TO 2-PYRROLIDINONE-5-CARBOXALDEHYDE, Synthetic communications, 26(16), 1996, pp. 3137-3150
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
26
Issue
16
Year of publication
1996
Pages
3137 - 3150
Database
ISI
SICI code
0039-7911(1996)26:16<3137:SAT2>2.0.ZU;2-G
Abstract
We have examined routes for the preparation of 2-pyrrolidinone-5S-carb oxaldehyde which include oxidation of 5-hydroxymethyl-2-pyrrolidinone and reduction of 5-oxoproline ethylester. Only the oxidation route pro ved satisfactory. Moffatt oxidation was most efficient but PCC oxidati on gave modest yields of the desired aldehyde.