TRIGGERING OF OVULATION BY A GONADOTROPIN-RELEASING-HORMONE (GNRH) AGONIST IN PATIENTS PRETREATED WITH A GNRH ANTAGONIST

Objective: To determine if GnRH-agonist (GnRH-a) could induce a LH sur ge in patients where a GnRH antagonist was used to prevent premature s pontaneous LH surge. Design: Pilot study. Patients: Five patients trea ted with ovarian stimulation and IUI for idiopathic infertility. Main Outcome Measures: Luteinizing hormone, FSH, and P plasma levels. Resul ts: A LH and FSH surge as well as a P rise were obtained in the five p atients studied. Conclusion: A GnRH-a successfully can induce an LH su rge after GnRH antagonist administration. The effect of the antagonist on the quality of the GnRH-a-induced LH surge as well as the oocyte q uality remain to be evaluated.