The combination of flexible endoscopy and laparoscopy has allowed a cr
eative approach to management of both benign and malignant gastrointes
tinal diseases. Historically, attempts to incorporate intraluminal end
oscopy with laparoscopy were made early in the historical development
of laparoscopy, especially as an aid to stage gastric cancer. The most
common modern application is that of flexible choledochoscopy by lapa
roscopic cholecystectomy. Other innovative uses include localization o
f tumors, control of upper gastrointestinal bleeding, gastric tumor ex
cision and biliary decompression, and bowel resection. With imaginatio
n guided by sound surgical principles, the combined use of laparoscopy
and intraluminal endoscopy should expand the boundaries of general su
rgery.