IMPROVED PASSIVE ORAL-DRUG DELIVERY VIA PRODRUGS

Authors
TAYLOR MD
Citation
Md. Taylor, IMPROVED PASSIVE ORAL-DRUG DELIVERY VIA PRODRUGS, Advanced drug delivery reviews, 19(2), 1996, pp. 131-148
Citations number
97
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Advanced drug delivery reviews → ACNP
ISSN journal
0169409X
Volume
19
Issue
2
Year of publication
1996
Pages
131 - 148
Database
ISI
SICI code
0169-409X(1996)19:2<131:IPODVP>2.0.ZU;2-M
Abstract
Employing prodrugs to improve drug delivery and oral absorption, in pa rticular, is a proven strategy. This review describes recent examples of prodrugs intended to improve oral delivery through enhanced passive transcellular absorption. The underlying biophysics of passive transc ellur transport also is discussed as a framework for prodrug design.