QUINAZOLINONE DERIVATIVES - SYNTHESIS AND BINDING EVALUATION ON CHOLECYSTOKININ RECEPTORS

Authors
VARNAVAS A LASSIANI L LUXICH E ZACCHIGNA M BOCCU E
Citation
A. Varnavas et al., QUINAZOLINONE DERIVATIVES - SYNTHESIS AND BINDING EVALUATION ON CHOLECYSTOKININ RECEPTORS, Il Farmaco, 51(5), 1996, pp. 333-339
Citations number
26
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
51
Issue
5
Year of publication
1996
Pages
333 - 339
Database
ISI
SICI code
0014-827X(1996)51:5<333:QD-SAB>2.0.ZU;2-N
Abstract
A series of 2-methyl-3-amino-4(H)-quinazolinone and of 2-phenyl-3-amin o-4(H)-quinazolinone derivatives were synthesized and examined for the ir CCK receptor affinities. These compounds displayed micromolar affin ities for CCK-B rather than CCK-A receptor and the obtained results co nfirm that the 4(3H)-quinazolinone nucleous represent a useful templat e for the development of selective CCK-B receptor ligands.