BACK-TO-BACK ONE-POT [F-18] FDG SYNTHESES IN A SINGLE SIEMENS-CTI CHEMISTRY PROCESS-CONTROL UNIT

Simple changes in the chemistry, plumbing, and programming of the Siem ens CTI chemistry process control unit (CPCU) effectively double its o utput by enabling two back-to back ''1-pot'' syntheses of 2-[F-18]fluo ro-2-deoxy-D-glucose in a single unit. Replacement of Kryptofix 2.2.2 with tetramethylammonium carbonate and elimination of diethyl ether fr om the procedure shorten synthesis time to 48 min, improve process and end product safety, and increase end-of-synthesis yields from 37% to 52% by minimizing steps and transfer losses.