A RADIOIMMUNOIMAGING AND MIRD DOSIMETRY TREATMENT PLANNING PROGRAM FOR RADIOIMMUNOTHERAPY

Authors
ERWIN WD GROCH MW MACEY DJ DENARDO GL DENARDO SJ SHEN S
Citation
Wd. Erwin et al., A RADIOIMMUNOIMAGING AND MIRD DOSIMETRY TREATMENT PLANNING PROGRAM FOR RADIOIMMUNOTHERAPY, Nuclear medicine and biology, 23(4), 1996, pp. 525-532
Citations number
45
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
Nuclear medicine and biology
ISSN journal
09698051 → ACNP
Volume
23
Issue
4
Year of publication
1996
Pages
525 - 532
Database
ISI
SICI code
0969-8051(1996)23:4<525:ARAMDT>2.0.ZU;2-L
Abstract
A treatment planning program for radioimmunotherapy employing quantita tive Anger camera imaging and the MIRD formalism has been designed and implemented on a clinical nuclear medicine computer. Radionuclide res idence times are calculated from linear, mono- and bi exponential, and cubic spline fits to regional activity versus time curves, and radiat ion-absorbed dose estimates for all target organs for I-131, Cu-67, an d 58 other radionuclides can be calculated. This software has been suc cessfully applied to radioimmunotherapy of B-cell malignancies and bre ast adenocarcinomas.