THE CELLULAR AND MOLECULAR MECHANISMS OF DIABETIC COMPLICATIONS

Authors
KING GL BROWNLEE M
Citation
Gl. King et M. Brownlee, THE CELLULAR AND MOLECULAR MECHANISMS OF DIABETIC COMPLICATIONS, Endocrinology and metabolism clinics of North America, 25(2), 1996, pp. 255
Citations number
80
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Endocrinology and metabolism clinics of North America → ACNP
ISSN journal
08898529
Volume
25
Issue
2
Year of publication
1996
Database
ISI
SICI code
0889-8529(1996)25:2<255:TCAMMO>2.0.ZU;2-7
Abstract
Hyperglycemia-induced mechanisms that may induce diabetic vascular dys function include increased polyol pathway flux, altered cellular redox state, increased formation of diacylglycerol, the subsequent activati on of protein kinase C isoforms, and accelerated nonenzymatic formatio n of advanced glycation end products. Growth factor abnormalities and insulin resistance also may have a role.