BCR ABL MODULATES THE CYTOKINE AND RETINOIC ACID RESPONSE OF C-REL INHUMAN MYELOID CELLS/

A human myeloid cell line, Mo7, and a daughter cell line expressing th e bcr/abl oncogene, Mo7-P210, were used in a comparative study analyzi ng the effects of p210(BCR/ABL) expression on tyrosine phosphorylation , specific DNA binding and expression of c-Rel was indistingushable in both cell lines. Tyrosine phosphorylation and DNA binding of c-Rel we re slightly elevated in Mo7-P210 cells. Further, Mo7 and Mo7-P210 cell s showed different responses concerning c-Rel after stimulation with c ytokines and retinoic acid. The results presented here demonstrate tha t c-Rel can be modulated by hematopoietic cytokines and suggest that b cr/abl expression has an impact on these responses and that c-Rel may be a downstream effector for p210(BCR/ABL).