Systemic acquired resistance (SAR) appears to be a ubiquitous higher p
lant defence response. Resistance is dependent on the high-level expre
ssion of SAR genes. Mutations, transgenes or chemicals that cause high
-level SAR gene expression also cause resistance to pathogens. Further
more, when SAR is eliminated, through the reduction of salicylic acid
accumulation or activity, generalized severe disease-susceptibility oc
curs. Therefore, SAR appears to be an essential component of the defen
sive repertoire that ensures plant health in nature. Chemicals that ac
tivate SAR in the field, as well as crop varieties with constitutive S
AR gene expression, will provide new solutions to disease problems for
growers in the near future.