AN ALTERNATIVE METHOD FOR THE DETERMINATION OF CHLORIDE IN PHARMACEUTICAL DRUG SUBSTANCES USING HPLC AND EVAPORATIVE LIGHT-SCATTERING DETECTION

Authors
RISLEY DS PETERSON JA GRIFFITHS KL MCCARTHY S
Citation
Ds. Risley et al., AN ALTERNATIVE METHOD FOR THE DETERMINATION OF CHLORIDE IN PHARMACEUTICAL DRUG SUBSTANCES USING HPLC AND EVAPORATIVE LIGHT-SCATTERING DETECTION, LC GC, 14(12), 1996, pp. 1040
Citations number
30
Categorie Soggetti
Chemistry Analytical
Journal title
LC GC → ACNP
ISSN journal
08889090
Volume
14
Issue
12
Year of publication
1996
Database
ISI
SICI code
0888-9090(1996)14:12<1040:AAMFTD>2.0.ZU;2-R
Abstract
Researchers traditionally have analyzed inorganic ions such as chlorid e in pharmaceutical drug substances by ion chromatography (IC) with co nductivity detection or titration methods. The authors have developed a new quantitative method for the determination of chloride in pharmac eutical drug substances using high performance liquid chromatography ( HPLC) with evaporative light-scattering detection, They compare the an alyses of chloride in 17 pharmaceutical drug substances (hydrochloride salts) using HPLC analysis with evaporative light-scattering detectio n (ELSD) against the theoretical chloride content based on empirical f ormulas. In addition, they statistically compare chloride results obta ined by IC, capillary electrophoresis, and titration methods with resu lts obtained by HPLC-ELSD.