MICROBIAL TRANSFORMATION OF TAXOIDS - SELECTIVE DEACETYLATION AND HYDROXYLATION OF A,10-BETA,14-BETA-TETRA-ACETOXY-4(20),11-TAXADIENE BY THE FUNGUS CUNNINGHAMELLA-ECHINULATA

Authors
HU SH TIAN XF ZHU WH FANG QC
Citation
Sh. Hu et al., MICROBIAL TRANSFORMATION OF TAXOIDS - SELECTIVE DEACETYLATION AND HYDROXYLATION OF A,10-BETA,14-BETA-TETRA-ACETOXY-4(20),11-TAXADIENE BY THE FUNGUS CUNNINGHAMELLA-ECHINULATA, Tetrahedron, 52(26), 1996, pp. 8739-8746
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
26
Year of publication
1996
Pages
8739 - 8746
Database
ISI
SICI code
0040-4020(1996)52:26<8739:MTOT-S>2.0.ZU;2-4
Abstract
The fungal genus Cunninghamella, in particular, Cunninghamella echinul ata AS 3.1990 selectively transformed 2 alpha,5 alpha,10 beta,14 beta- tetra-acetoxy-4(20),11-taxadiene(1) to give 6 alpha,10 beta-dihydroxy- 2 alpha,5 alpha,14 beta-triacetoxy-4(20),11-taxadiene(2) in moderate yield (33%), along with 6 beta,10 beta-dihydroxy-2 alpha,5 alpha,14 be ta-triacetoxy-4(20),11-taxadiene(3), 10 beta-hydroxy-2 alpha,5 alpha,1 4 beta-triacetoxy-taxadiene(4), 10 beta-hydroxy-4 beta,20-epoxy-2 alph a 5 alpha,14 beta-triacetoxy-tax-11-ene(5) as minor products. Copyrigh t (C) 1996 Elsevier Science Ltd