EPINARDINS A-D, NEW PYRROLOIMINOQUINONE ALKALOIDS OF UNDETERMINED DEEP-WATER GREEN DEMOSPONGES FROM PRE-ANTARCTIC INDIAN-OCEAN

Authors
DAMBROSIO M GUERRIERO A CHIASERA G PIETRA F
Citation
M. Dambrosio et al., EPINARDINS A-D, NEW PYRROLOIMINOQUINONE ALKALOIDS OF UNDETERMINED DEEP-WATER GREEN DEMOSPONGES FROM PRE-ANTARCTIC INDIAN-OCEAN, Tetrahedron, 52(26), 1996, pp. 8899-8906
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
26
Year of publication
1996
Pages
8899 - 8906
Database
ISI
SICI code
0040-4020(1996)52:26<8899:EANPAO>2.0.ZU;2-R
Abstract
Four novel pyrroloiminoquinone alkaloids that differ from members of t he discorhabdin/prianosin family for having an allylic alcohol functio nality in place of the enone system, epinardins A-D (8-11), have been isolated from undetermined deep-water green demosponges collected in p re-Antarctic waters near the Crozet Islands. Relative stereochemistry has been fully assigned from high-field NMR spectra. Epinardin C (10) proved strongly cytotoxic towards doxorubicin-resistant L1210/DX tumou ral cells in vitro. (C) 1996 Elsevier Science Ltd