STRUCTURAL AND IMMUNOLOGICAL CHARACTERIZATION OF BURKHOLDERIA-PSEUDOMALLEI O-POLYSACCHARIDE-FLAGELLIN PROTEIN CONJUGATES

Authors
BRETT PJ WOODS DE
Citation
Pj. Brett et De. Woods, STRUCTURAL AND IMMUNOLOGICAL CHARACTERIZATION OF BURKHOLDERIA-PSEUDOMALLEI O-POLYSACCHARIDE-FLAGELLIN PROTEIN CONJUGATES, Infection and immunity, 64(7), 1996, pp. 2824-2828
Citations number
27
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
64
Issue
7
Year of publication
1996
Pages
2824 - 2828
Database
ISI
SICI code
0019-9567(1996)64:7<2824:SAICOB>2.0.ZU;2-J
Abstract
The O-polysaccharide moiety of Burkholderia pseudomallei 319a lipopoly saccharide was covalently linked to flagellin protein isolated from th e same strain. A glycoconjugate incorporating adipic acid dihydrazide as a spacer molecule elicited high-titer immunoglobulin G responses to both the protein and carbohydrate components of the construct. This i mmunoglobulin G was capable of protecting diabetic rats from challenge with a heterologous B. pseudomallei strain.