PURIFIED CAPSULAR POLYSACCHARIDE OF CRYPTOCOCCUS-NEOFORMANS INDUCES INTERLEUKIN-10 SECRETION BY HUMAN MONOCYTES

Authors
VECCHIARELLI A RETINI C MONARI C TASCINI C BISTONI F KOZEL TR
Citation
A. Vecchiarelli et al., PURIFIED CAPSULAR POLYSACCHARIDE OF CRYPTOCOCCUS-NEOFORMANS INDUCES INTERLEUKIN-10 SECRETION BY HUMAN MONOCYTES, Infection and immunity, 64(7), 1996, pp. 2846-2849
Citations number
15
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
64
Issue
7
Year of publication
1996
Pages
2846 - 2849
Database
ISI
SICI code
0019-9567(1996)64:7<2846:PCPOCI>2.0.ZU;2-U
Abstract
In this study, we demonstrated that purified capsular poly saccharide of Cryptococcus neoformans is a potent inducer of interleukin-10 (IL-1 0) secretion by human monocytes. Endogenous IL-10 was involved in regu lating tumor necrosis factor alpha and IL-1 beta secretion by human mo nocytes in response to encapsulated C. neoformans strains. Our results suggest a new immunosuppressive effect exerted by glucuronoxylomannan through the induction of IL-10, a potent downregulator of proinflamma tory cytokines.