TOXIN-COREGULATED PILUS, BUT NOT MANNOSE-SENSITIVE HEMAGGLUTININ, IS REQUIRED FOR COLONIZATION BY VIBRIO-CHOLERAE O1 EL-TOR BIOTYPE AND O139 STRAINS

Authors
THELIN KH TAYLOR RK
Citation
Kh. Thelin et Rk. Taylor, TOXIN-COREGULATED PILUS, BUT NOT MANNOSE-SENSITIVE HEMAGGLUTININ, IS REQUIRED FOR COLONIZATION BY VIBRIO-CHOLERAE O1 EL-TOR BIOTYPE AND O139 STRAINS, Infection and immunity, 64(7), 1996, pp. 2853-2856
Citations number
38
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
64
Issue
7
Year of publication
1996
Pages
2853 - 2856
Database
ISI
SICI code
0019-9567(1996)64:7<2853:TPBNMH>2.0.ZU;2-Y
Abstract
The relative contributions of toxin-coregulated pilus (TCP) and cell-a ssociated mannose-sensitive hemagglutinin (MSHA) to the colonization a bility of Vibrio cholerae O1 El Tor biotype strains and O139 Bengal st rains was determined by using isogenic parental and in-frame deletion mutant pairs in the infant mouse cholera model. Both the El Tor and O1 39 tcpA mutant strains showed a dramatic defect in colonization as ind icated by their competitive indices, whereas deletion of mshA had a ne gligible effect on colonization in either background.