THE ROLE OF D-1 AND D-2 DOPAMINE-RECEPTORS IN MOTOR BEHAVIOR OF PATIENTS WITH PARKINSONS-DISEASE

The dopamine D-1 and D-2 receptors are differentiated by both their lo cations in the basal ganglia, and the striatal output pathways with wh ich they are associated. Nevertheless, both these subtypes appear to p lay a role in motor behaviour in Parkinson's disease, This paper discu sses the differentiation of the two receptor subtypes, and the experim ental evidence for their roles in Parkinson's disease, Proposals are p ut forward, in the light of this experimental evidence using selective agonists, for the ideal form of treatment for Parkinson's disease, in terms of dopamine receptor stimulation.