DISTRIBUTION EQUILIBRIUM OF PENICILLIN-G BETWEEN WATER AND ORGANIC SOLUTIONS OF AMBERLITE LA-2

Equilibrium studies on the distribution of penicillin G between aqueou s solutions and Amberlite LA-2 (a secondary amine) in mixtures of n-bu tyl acetate and kerosene were made in the temperature range 288-308 K. Experiments were performed as a function of aqueous pH, penicillin G concentration in the aqueous phase, and amine concentration in the org anic phase. The composition of the complex present in the organic phas e and the equilibrium constant for the formation of this complex were numerically determined at different temperatures. In addition, the app arent enthalpy and entropy for complexation reaction were calculated.