ELEVATED FREQUENCY OF THE C2 ALLELE OF THE ETS-I ONCOGENE IN ELDERLY SUBJECTS

Authors
CROSSEN PE MORRISON MJ
Citation
Pe. Crossen et Mj. Morrison, ELEVATED FREQUENCY OF THE C2 ALLELE OF THE ETS-I ONCOGENE IN ELDERLY SUBJECTS, Mechanism of ageing and development, 88(1-2), 1996, pp. 61-65
Citations number
12
Categorie Soggetti
Geiatric & Gerontology",Biology,"Cell Biology
Journal title
Mechanism of ageing and development → ACNP
ISSN journal
00476374
Volume
88
Issue
1-2
Year of publication
1996
Pages
61 - 65
Database
ISI
SICI code
0047-6374(1996)88:1-2<61:EFOTCA>2.0.ZU;2-R
Abstract
We studied the frequency of an SstI polymorphism of the ETS-1 oncogene in 122 elderly subjects (mean age 78.14 years) and 115 teenagers (mea n age 16.9 years). No difference in the frequency of the three genotyp es (C1C1, C1C2, C2C2) was found between the two groups. However, the C 2 allele occurred more frequently in the elderly subjects (chi(2) = 5. 49, P < 0.02). These data suggest that the presence of the C2 allele m ay be associated with survival to old age.