HEMORRHEOLOGIC EFFECTS OF METABOLITES OF PENTOXIFYLLINE (TRENTAL(R))

Pentoxifylline (Trental(R)) is metabolized by red blood cells and the liver into seven metabolites. Metabolites I and V have significant hem orrheologic effects. They are both similar to pentoxifylline in their activity on red blood cell membrane fluidity. Metabolite I is more act ive than pentoxifylline in inhibiting ADP-induced platelet aggregation . Metabolite V is more active than pentoxifylline in inhibiting epinep hrine-induced platelet aggregation.