NUCLEIC-ACID BINDING BY ZINC FINGER-LIKE MOTIF OF HUMAN PAPILLOMAVIRUS TYPE-16 E7 ONCOPROTEIN

Authors
CHINAMI M INOUE M MASUNAGA K FUKUMA T SHINGU M TOYODA T
Citation
M. Chinami et al., NUCLEIC-ACID BINDING BY ZINC FINGER-LIKE MOTIF OF HUMAN PAPILLOMAVIRUS TYPE-16 E7 ONCOPROTEIN, Journal of virological methods, 59(1-2), 1996, pp. 173-176
Citations number
21
Categorie Soggetti
Virology,"Biochemical Research Methods","Biothechnology & Applied Migrobiology
Journal title
Journal of virological methods → ACNP
ISSN journal
01660934
Volume
59
Issue
1-2
Year of publication
1996
Pages
173 - 176
Database
ISI
SICI code
0166-0934(1996)59:1-2<173:NBBZFM>2.0.ZU;2-T
Abstract
Human papillomavirus (HPV) types 16 and 6b E7 proteins and their chime ric or mutant proteins were analyzed for oligonucleotide-binding activ ity by surface plasmon resonance-based biomolecular interaction analys is. The results indicated that type 16 E7 protein has stronger nucleic acid-binding activity than that of type 6b E7 protein. In addition, t he results also indicated that the zinc finger-like motif in the C-ter minal region of the type 16 E7 protein plays an important role in this activity.