M. Chinami et al., NUCLEIC-ACID BINDING BY ZINC FINGER-LIKE MOTIF OF HUMAN PAPILLOMAVIRUS TYPE-16 E7 ONCOPROTEIN, Journal of virological methods, 59(1-2), 1996, pp. 173-176
Citations number
21
Categorie Soggetti
Virology,"Biochemical Research Methods","Biothechnology & Applied Migrobiology
Human papillomavirus (HPV) types 16 and 6b E7 proteins and their chime
ric or mutant proteins were analyzed for oligonucleotide-binding activ
ity by surface plasmon resonance-based biomolecular interaction analys
is. The results indicated that type 16 E7 protein has stronger nucleic
acid-binding activity than that of type 6b E7 protein. In addition, t
he results also indicated that the zinc finger-like motif in the C-ter
minal region of the type 16 E7 protein plays an important role in this
activity.