INDUCTION OF BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AND THE RECEPTOR TRK-B MESSENGER-RNA FOLLOWING MIDDLE CEREBRAL-ARTERY OCCLUSION IN RAT

Authors
ARAI S KINOUCHI H AKABANE A OWADA Y KAMII H KAWASE M YOSHIMOTO T
Citation
S. Arai et al., INDUCTION OF BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AND THE RECEPTOR TRK-B MESSENGER-RNA FOLLOWING MIDDLE CEREBRAL-ARTERY OCCLUSION IN RAT, Neuroscience letters, 211(1), 1996, pp. 57-60
Citations number
26
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
211
Issue
1
Year of publication
1996
Pages
57 - 60
Database
ISI
SICI code
0304-3940(1996)211:1<57:IOBNF(>2.0.ZU;2-Y
Abstract
Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced brain-derived neurotrophic factor (BDNF) and the receptor, Irk B mRNA, in brain. In situ hybridization studies showed that BDNF and Irk B mRNAs were induced in a widespread region of the ipsilateral cor tex outside the infarct at 4 h following MCA occlusion. They were also induced in the bilateral hippocampi which are remote from the ischemi c MCA region. These data show that changes in neurotrophic factor and receptor gene expressions can occur in the areas outside the infarct w hich could survive.