EXPRESSION OF PROTEIN-TYROSINE KINASES IN THE MURINE THYMUS STROMA

Citation
Ef. Potworowski et C. Beauchemin, EXPRESSION OF PROTEIN-TYROSINE KINASES IN THE MURINE THYMUS STROMA, Immunology letters, 50(1-2), 1996, pp. 65-69
Citations number
21
Categorie Soggetti
Immunology
Journal title
ISSN journal
01652478
Volume
50
Issue
1-2
Year of publication
1996
Pages
65 - 69
Database
ISI
SICI code
0165-2478(1996)50:1-2<65:EOPKIT>2.0.ZU;2-7
Abstract
Thymocytes not only receive signals from thymic epithelial cells but c an also activate the latter, at least in the medulla. We have previous ly reported tyrosine phosphorylation of medullary epithelial cell subs trates, after co-culture with thymocytes, and identified a number of p rotein tyrosine kinases in a line of thymic epithelial cells. We repor t here the in situ localisation by immunohistochemistry of JAK2 in med ullary epithelial cells, of PDGF-R in medullary vascular endothelium, of FGF-R in Hassall's corpuscles, and the weak expression of JAK1 and RYK throughout the thymus.