RISPERIDONE IN THE TREATMENT OF MANIA

Citation
M. Tohen et al., RISPERIDONE IN THE TREATMENT OF MANIA, The Journal of clinical psychiatry, 57(6), 1996, pp. 249-253
Citations number
29
Categorie Soggetti
Psycology, Clinical",Psychiatry,Psychiatry
ISSN journal
01606689
Volume
57
Issue
6
Year of publication
1996
Pages
249 - 253
Database
ISI
SICI code
0160-6689(1996)57:6<249:RITTOM>2.0.ZU;2-D
Abstract
Background: Risperidone, a 5-HT2 and D, antagonist, has been shown to be an effective antipsychotic in the treatment of schizophrenia but ha s unclear efficacy in the treatment of psychotic affective disorders. The purpose of the study was to assess the efficacy of risperidone in the treatment of acute mania with psychotic features. Method: We condu cted an open-label pilot study of risperidone and concurrent mood-stab ilizing drugs in the treatment of acute mania with psychotic features. Patients were diagnosed with the Structured Clinical Interview for DS M-III-R (SCID). Efficacy was measured weekly with the use of the Young Mania Rating Scale (YMRS) and the Brief Psychiatric Rating Scale (BPR S). Results: Ten women and 5 men (mean age = 38 years) were included i n the study. Of the 13 patients who completed 2 weeks of treatment, 8 of these 13 had a 50% improvement of the BPRS, and all 13 had at least a 25% improvement (p = .002, 95% confidence interval [CI] = 46.0 to 5 7.8). Of the 8 patients who completed 6 weeks of treatment, 7 of the 8 had a 50% improvement, and all 8 had a 25% improvement (p = .012, 95% CI = 52.4 to 69.3). Similar results were obtained with the YMRS. By t he second week of treatment, 10 of the 13 patients remaining in treatm ent had at least a 50% improvement, and 12 of these 13 had a 25% impro vement (p = .002, 95% CI = 55.1 to 89.9). By the sixth week, all of th e 8 patients remaining in treatment had a 75% improvement (p = .012, 9 5% CI = 90.5 to 102.8). The medication was well tolerated, and no case worsened. Conclusion: When used with concomitant mood-stabilizing dru gs, risperidone may be effective and well tolerated in patients with a cute mania with psychotic features. Considering the open design, small sample size, and limited period of observation, further studies need to be conducted.