Ra. Hiatt et al., RANDOMIZED CONTROLLED TRIAL OF A LOW ANIMAL PROTEIN, HIGH-FIBER DIET IN THE PREVENTION OF RECURRENT CALCIUM-OXALATE KIDNEY-STONES, American journal of epidemiology, 144(1), 1996, pp. 25-33
Low protein diets are commonly prescribed for patients with idiopathic
calcium nephrolithiasis, who account for >80% of new diagnoses of kid
ney stones, This dietary advice is supported by metabolic studies and
epidemiologic observational studies but has not been evaluated in a co
ntrolled trial, Using 1983-1985 data from three Northern California Ka
iser Permanente Medical Centers, the authors randomly assigned 99 pers
ons who had calcium oxalate stones for the first time to a low animal
protein, high fiber diet that contained approximately 56-64 g daily of
protein, 75 mg daily of purine (primarily from animal protein and leg
umes), one-fourth cup of wheat bran supplement, and fruits and vegetab
les. Intervention subjects were also instructed to drink six to eight
glasses of liquid daily and to maintain adequate calcium intake from d
airy products or calcium supplements. Control subjects were instructed
only on fluid intake and adequate calcium intake. Both groups were fo
llowed regularly for up to 4.5 years with food frequency questionnaire
s, serum and urine chemistry analysis, and abdominal radiography; and
they were urged to comply with dietary instructions. In the interventi
on group of 50 subjects, stones recurred in 12 (7.1 per 100 person-yea
rs) compared with two (1.2 per 100 person-years) in the control group;
both groups received a mean of 3.4 person-years of follow-up (p = 0.0
06). After adjustment for possible confounding effects of age, sex, ed
ucation, and baseline protein and fluid intake, the relative risk of a
recurrent stone in the intervention group was 5.6 (95% confidence int
erval 1.2-26.1) compared with the control group, The authors conclude
that advice to follow a low animal protein, high fiber, high fluid die
t has no advantage over advice to increase fluid intake alone.