Mr. Horsman et al., THE IN-VIVO INTERACTION BETWEEN FLAVONE ACETIC-ACID AND HYPERTHERMIA, International journal of hyperthermia, 12(6), 1996, pp. 779-789
Citations number
47
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging",Oncology
The in vivo interaction between flavone acetic acid (FAA) and hyperthe
rmia was studied in a C3H mammary carcinoma grown in the feet of femal
e CDF1 mice and in normal foot skin. FAA was intraperitoneally injecte
d prior to local tissue heating in restrained non-anaesthetized animal
s. Alone, FAA at doses of 100 mg/kg and above, inhibited tumour growth
in a dose-dependent fashion. FAA also enhanced the tumour response to
heat, the effect being dependent on both the time interval between th
e two modalities and the FAA dose, the greatest effect occurring when
FAA doses of greater than or equal to 150 mg/kg preceeded heat by 3-48
h. These effects of FAA correlated with the drug's ability to decreas
e tumour blood perfusion measured using the RbCl extraction procedure.
Injecting 150 mg/kg FAA 3 h before heating (42.7 degrees C) resulted
in a 2.2-fold increase in tumour heat damage, but had little effect on
the response of normal foot skin in non-tumour-bearing mice. However,
this treatment gave a 2.0-fold increase in normal tissue damage when
the skin experiments were repeated in tumour-bearing animals. These ef
fects in skin occurred in the absence of any blood perfusion changes,
but appeared to be associated with FAA-induced TNF-alpha production.