EFFECT OF AMINO-ACIDS ON THE STABILITY PROPERTIES OF NITROFURANTOIN SUSPENSIONS - FLOCCULATION AND REDISPERSION COMPARED WITH INTERACTION ENERGY CURVES

Authors
GALLARDO V RUIZ MA VERA P GONZALEZCABALLERO F DELGADO AV
Citation
V. Gallardo et al., EFFECT OF AMINO-ACIDS ON THE STABILITY PROPERTIES OF NITROFURANTOIN SUSPENSIONS - FLOCCULATION AND REDISPERSION COMPARED WITH INTERACTION ENERGY CURVES, Journal of Pharmacy and Pharmacology, 48(5), 1996, pp. 450-455
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of Pharmacy and Pharmacology → ACNP
ISSN journal
00223573
Volume
48
Issue
5
Year of publication
1996
Pages
450 - 455
Database
ISI
SICI code
0022-3573(1996)48:5<450:EOAOTS>2.0.ZU;2-9
Abstract
The influence of the addition of amino acids, lysine, alanine and glut amic acid on the properties of nitrofurantoin suspensions was investig ated. Flocculation and redispersability was investigated, taking into account the electrical properties of the nitrofitrantoin/solution inte rface. We conclude that lysine and glutamic acid, but not alanine, wou ld be suitable amino acids for control of the stability of nitrofurant oin suspensions.