GABA(A) RECEPTOR ALPHA(1)-SUBUNIT-IMMUNOPOSITIVE NEURONS IN THE RAT STRIATUM

Citation
Hj. Caruncho et al., GABA(A) RECEPTOR ALPHA(1)-SUBUNIT-IMMUNOPOSITIVE NEURONS IN THE RAT STRIATUM, Brain research, 722(1-2), 1996, pp. 185-189
Citations number
21
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
00068993
Volume
722
Issue
1-2
Year of publication
1996
Pages
185 - 189
Database
ISI
SICI code
0006-8993(1996)722:1-2<185:GRANIT>2.0.ZU;2-7
Abstract
The morphological characteristics and distribution of striatal neurons expressing the GABA(A) receptor alpha(1)-subunit were investigated fo llowing immunolabeling with an alpha(1)-subunit-specific antibody. alp ha(1)-Immunopositive striatal neurons are relatively scarce. Those loc ated in the dorsal striatum are small and have rounded somata and nume rous dendrite varicosities. alpha(1)-Immunoreactive neurons with these characteristics were likewise observed in the ventral striatum, which also contained large pyramidal neurons with smooth dendrites and poly gonal neurons with spiny dendrites. A fourth neuron type (oval neurons with dendrites oriented in bipolar fashion) was found in the lateral striatum. All four neuron types were observed in the rostral, central and caudal striatum. Double-labeling experiments using an antibody spe cific for DARPP-32 (a cell-level indicator of dopamine D1-like recepto rs) and the alpha(1) antibody showed a complete lack of colocalization of these two markers in striatal neurons.