DETECTION OF HEPATITIS-B VIRUS GENOME IN HEPATOCELLULAR-CARCINOMA FROM BOTH HEPATITIS-B SURFACE ANTIGEN AND ANTIBODY TO HEPATITIS-C VIRUS-NEGATIVE PATIENTS - A STUDY USING POLYMERASE CHAIN-REACTION

Authors
KAMITO H NAKATA K HAMASAKI K DAIKOKU M MAWATARI F UEKI T HAYASHIDA Y NAKAO K KATO Y NAGATAKI S
Citation
H. Kamito et al., DETECTION OF HEPATITIS-B VIRUS GENOME IN HEPATOCELLULAR-CARCINOMA FROM BOTH HEPATITIS-B SURFACE ANTIGEN AND ANTIBODY TO HEPATITIS-C VIRUS-NEGATIVE PATIENTS - A STUDY USING POLYMERASE CHAIN-REACTION, Oncology Reports, 3(4), 1996, pp. 619-623
Citations number
30
Categorie Soggetti
Oncology
Journal title
Oncology Reports → ACNP
ISSN journal
1021335X
Volume
3
Issue
4
Year of publication
1996
Pages
619 - 623
Database
ISI
SICI code
1021-335X(1996)3:4<619:DOHVGI>2.0.ZU;2-D
Abstract
Twenty-two patients who tested seronegative for both hepatitis B virus (HBV) and hepatitis C virus (HCV) markers and undefined pathogenesis of hepatocellular carcinoma (HCC) were studied using polymerase chain reaction (PCR). Among these patients, 5 (23%) were positive for HBV-DN A in serum by PCR, but no patient was positive for HCV-RNA by reverse transcription PCR. Liver tissue specimens were available for analyzing HBV genome by PCR in 17 patients, and HBV sequences were detected in 10 (59%) patients. These results indicate that HBV is commonly implica ted in serologically undefined pathogenesis of HCC in Japan.