NUCLEAR MATRIX OF HUMAN NASOPHARYNGEAL CARCINOMA-CELLS IN CULTURE - APRELIMINARY-REPORT

Nuclear matrix is a scaffold-like structure of the nucleus after seque ntial treatments with detergents, DNase, and high salt buffers. Its in volvement in various cellular activities has been emphasised in variou s studies. In this study, nuclear matrix of two human nasopharyngeal c arcinoma cell Lines were compared and analysed in terms of their morph ological appearance and electrophoretic patterns of proteins. The stab ility of nuclear matrices against enzymatic digestion was found to be similar in these two cell lines. However, cell line specific nuclear m atrix proteins were detected in each cell line. The significance of th ese proteins in cellular function and oncogenesis will be investigated in due course.