PS2 PROTEIN DETECTED BY IMMUNOHISTOCHEMISTRY IN ARCHIVAL PRIMARY BREAST-CANCER - PROGNOSTIC VALUE AND LONG-TERM FOLLOW-UP IN 219 PATIENTS

It has been proposed that pS2 protein in breast cancer provides inform ation on the individual prognosis and biological properties of the tum or with respect to response to endocrine treatment. In this retrospect ive study the pS2 protein expression was detected by immunohistochemis try in formalin-fixed, paraffin-embedded breast cancer sections from 2 19 patients with primary breast cancer. The data were compared with pa tients' age, disease stage and tumor grading tumor estrogen and proges terone receptor status, disease-free interval and overall survival. Do cumented follow-up of up to 138 months with a mean of 69 months was an alysed. 54% of the tumors were pS2-positive. There was a significant p ositive correlation with steroid receptor content. There was no correl ation of pS2 with patient age, staging or grading pS2 could not contri bute more prognostic information beyond steroid receptor status or axi llary lymph node involvement. Survival analysis of the pS2-positive an d negative. tumor patients failed to show a significant difference.