INDOMETHACIN LOADED CHITOSAN MICROSPHERES - CORRELATION BETWEEN THE EROSION PROCESS AND RELEASE KINETICS

Authors
ORIENTI I AIEDEH K GIANASI E BERTASI V ZECCHI V
Citation
I. Orienti et al., INDOMETHACIN LOADED CHITOSAN MICROSPHERES - CORRELATION BETWEEN THE EROSION PROCESS AND RELEASE KINETICS, Journal of microencapsulation, 13(4), 1996, pp. 463-472
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Applied","Engineering, Chemical
Journal title
Journal of microencapsulation → ACNP
ISSN journal
02652048
Volume
13
Issue
4
Year of publication
1996
Pages
463 - 472
Database
ISI
SICI code
0265-2048(1996)13:4<463:ILCM-C>2.0.ZU;2-O
Abstract
The preparation of chitosan microspheres covalently linked with citric acid and loaded with indomethacin is described. The release kinetics correlated with the concentration of chitosan in the microsphere prepa rative mixture and the pH of the release medium. Deviations from Ficki an to zero order kinetics were observed at higher concentrations of ch itosan and at pH 74. The variations induced by these parameters on dru g diffusion and solubility in the matrix undergoing erosion were analy sed.