SECONDARY ANTIBODIES AS TOOLS TO IMPROVE TUMOR TO NON TUMOR RATIO AT RADIOIMMUNOLOCALIZATION AND RADIOIMMUNOTHERAPY

One way of selectively improving the efficiency of radioimmunolocaliza tion and radioimmunotherapy is to eliminate redundant, circulating, no n-targeting radiolabeled antibodies after saturation of the target sit es. Secondary antibodies of different types have been proposed as clea ring agents for such purposes. The conceptually different approaches o f the 'secondary antibody' strategy including its advantages and limit ations are discussed. This mini-review also presents a model describin g the kinetics of the components (the antigen, the primary and seconda ry antibodies) and approaches required to improve the efficacy of both radioimmunolocalization and radioimmunotherapy.