ISOLATION OF 2 NEW ANTIINFLAMMATORY BIFLAVANOIDS FROM SARCOPHYTE-PIRIEI

Two new flavano flavanone glycosides, diinsininol (1) and diinsinin (2 ), have been isolated from the rhizome of Sarcophyte piriei, together with one known flavanone glycoside, naringenin 5-glucoside. Their stru ctures were elucidated on spectroscopic evidence as ,7,3',4'-tetrahydr oxyflavanyl-7-O-beta-glucosyl-(4 beta-8;2 beta-O-7)-eriodictyol (1) an d ,7,3',4'-tetrahydroxyflavanyl-7-O-beta-glucosyl-(4 beta-8;2 beta-O-7 )-naringenin (2), respectively. The compounds were tested for their ab ility to inhibit prostaglandin synthesis, with 1 and 2 giving IC50 val ues of 9.20 mu M and 13.14 mu M, respectively, and in the inhibition o f platelet-activating-factor-induced exocytosis, IC50 values of 49 and 39 mu M.