PROSTAGLANDIN-E2 DERIVATIVE, ENPROSTIL, REDUCES HEPATIC TRIACYLGLYCEROL CONTENT IN JAPANESE-QUAIL

This study investigated the effect of prostaglandin E(2) derivative, e nprostil, on the hepatic lipid metabolism of Japanese quail. In experi ment 1, the birds received 0.1, 1, 10 or 100 mu g enprostil/kg body we ight intraperitoneally, and they were killed after 10, 30, 60 and 120 min. After 60 min, hepatic triacylglycerol content was reduced most ef fectively by 10 mu g enprostil/kg body weight. In experiment 2, effect of enprostil (10 mu g/kg body weight) on liver enzyme activities asso ciated with lipid metabolism and plasma lipid concentrations was exami ned. There were no significant differences in malic enzyme and carniti ne palmitoyltransferase activities. Peroxisomal beta-oxidation in bird s which received enprostil was significantly lower than that in birds receiving the vehicle. Enprostil caused a significant decrease in plas ma triacylglycerol and non-esterified fatty acid concentration. We con clude that the administration of enprostil reduces hepatic triacylglyc erol content through the decreased influx of non-esterified fatty acid .